Novel Stem Cells and Nucleic Acid-Based Vaccine Trials Against Viral Outbreak: A Systematic Evaluation During COVID-2019 Pandemic.
Identifieur interne : 000109 ( Main/Exploration ); précédent : 000108; suivant : 000110Novel Stem Cells and Nucleic Acid-Based Vaccine Trials Against Viral Outbreak: A Systematic Evaluation During COVID-2019 Pandemic.
Auteurs : Chandan Kumar Maurya [Inde] ; Radhieka Misra [Inde] ; Praveen Sharma [Inde] ; Neha Singh [Inde] ; Harshita Awasthi [Inde] ; Ruchika Agrawal [Inde] ; Sanjeev Misra [Inde] ; Shailendra Dwivedi [Inde]Source :
- Indian journal of clinical biochemistry : IJCB [ 0970-1915 ] ; 2020.
Abstract
The current Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) outbreak, the cause of coronavirus disease (COVID-19), has influenced health globally. So far, there are no established management options and prophylaxis for those who have been exposed to SARS-CoV-2, and those who develop COVID-19. Documented scientific evidences in similar viral outbreaks in past suggested few therapy regimens. These rather have not shown promising results in management of current pandemic. So, in the current review, we are exploring novel treatment strategies and therapies that are being explored and are in clinical and preclinical stages of research. To explore more about the same, we directed our search towards stem cell based, DNA based, or RNA based vaccines against COVID-19 under development by various universities, institutes or pharmaceutical companies. The current scientific literature and database search were performed by exploring various Trials registry (NIH: https://clinicaltrials.gov/ and https://www.coronavirus.gov) and Chinese clinical trial registry http://www.chictr.org.cn/) and for preclinical trials various University, Institutions, Pharmaceutical companies websites and news bulletins along with google search were checked routinely from 3rd March 2020 to 16 May 2020. The term "Stem Cell therapy and COVID-19", "Mesenchymal stem cell and corona 2019 virus", "DNA Vaccines and COVID-19, RNA Vaccines and COVID-19" and "Cell-based therapy with SARS-CoV-2, University/Institutions and COVID-19 research" were used. The vaccine trials (Stem Cells/DNA/RNA) which were cancelled were not included in this review. Similarly, few others like repurposing of drugs, Nano Vaccines, other miscellaneous trials of Herbs, Music therapy etc., were also excluded. In the present review, we have included the various novel therapies like stem cell therapy, DNA or RNA vaccines which are under development and if proven successful may have a lasting impact on the health industry.
DOI: 10.1007/s12291-020-00907-4
PubMed: 32837030
PubMed Central: PMC7347658
Affiliations:
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Biochemistry, All India Institute of Medical Sciences, Gorakhpur, 273008 India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry, All India Institute of Medical Sciences, Gorakhpur</wicri:regionArea><wicri:noRegion>Gorakhpur</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32837030</idno><idno type="pmid">32837030</idno><idno type="doi">10.1007/s12291-020-00907-4</idno><idno type="pmc">PMC7347658</idno><idno type="wicri:Area/Main/Corpus">000143</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000143</idno><idno type="wicri:Area/Main/Curation">000143</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000143</idno><idno type="wicri:Area/Main/Exploration">000143</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Novel Stem Cells and Nucleic Acid-Based Vaccine Trials Against Viral Outbreak: A Systematic Evaluation During COVID-2019 Pandemic.</title><author><name sortKey="Maurya, Chandan Kumar" sort="Maurya, Chandan Kumar" uniqKey="Maurya C" first="Chandan Kumar" last="Maurya">Chandan Kumar Maurya</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, 273008 India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry, All India Institute of Medical Sciences, Gorakhpur</wicri:regionArea><wicri:noRegion>Gorakhpur</wicri:noRegion></affiliation></author><author><name sortKey="Misra, Radhieka" sort="Misra, Radhieka" uniqKey="Misra R" first="Radhieka" last="Misra">Radhieka Misra</name><affiliation wicri:level="1"><nlm:affiliation>Era's Lucknow Medical College, and Hospital, Lucknow, 226003 India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Era's Lucknow Medical College, and Hospital, Lucknow</wicri:regionArea><wicri:noRegion>Lucknow</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Praveen" sort="Sharma, Praveen" uniqKey="Sharma P" first="Praveen" last="Sharma">Praveen Sharma</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, 342005 India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur</wicri:regionArea><wicri:noRegion>Jodhpur</wicri:noRegion></affiliation></author><author><name sortKey="Singh, Neha" sort="Singh, Neha" uniqKey="Singh N" first="Neha" last="Singh">Neha Singh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biotechnology, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, 211007 India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biotechnology, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj</wicri:regionArea><wicri:noRegion>Prayagraj</wicri:noRegion></affiliation></author><author><name sortKey="Awasthi, Harshita" sort="Awasthi, Harshita" uniqKey="Awasthi H" first="Harshita" last="Awasthi">Harshita Awasthi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Lucknow University Lucknow, Lucknow, 226007 India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry, Lucknow University Lucknow, Lucknow</wicri:regionArea><wicri:noRegion>Lucknow</wicri:noRegion></affiliation></author><author><name sortKey="Agrawal, Ruchika" sort="Agrawal, Ruchika" uniqKey="Agrawal R" first="Ruchika" last="Agrawal">Ruchika Agrawal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ear Nose and Throat, All India Institute of Medical Sciences, Gorakhpur, 273008 India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Ear Nose and Throat, All India Institute of Medical Sciences, Gorakhpur</wicri:regionArea><wicri:noRegion>Gorakhpur</wicri:noRegion></affiliation></author><author><name sortKey="Misra, Sanjeev" sort="Misra, Sanjeev" uniqKey="Misra S" first="Sanjeev" last="Misra">Sanjeev Misra</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgical Oncology, All India Institute of Medical Sciences, Jodhpur, 342005 India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Surgical Oncology, All India Institute of Medical Sciences, Jodhpur</wicri:regionArea><wicri:noRegion>Jodhpur</wicri:noRegion></affiliation></author><author><name sortKey="Dwivedi, Shailendra" sort="Dwivedi, Shailendra" uniqKey="Dwivedi S" first="Shailendra" last="Dwivedi">Shailendra Dwivedi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, 273008 India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry, All India Institute of Medical Sciences, Gorakhpur</wicri:regionArea><wicri:noRegion>Gorakhpur</wicri:noRegion></affiliation></author></analytic><series><title level="j">Indian journal of clinical biochemistry : IJCB</title><idno type="ISSN">0970-1915</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The current Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) outbreak, the cause of coronavirus disease (COVID-19), has influenced health globally. So far, there are no established management options and prophylaxis for those who have been exposed to SARS-CoV-2, and those who develop COVID-19. Documented scientific evidences in similar viral outbreaks in past suggested few therapy regimens. These rather have not shown promising results in management of current pandemic. So, in the current review, we are exploring novel treatment strategies and therapies that are being explored and are in clinical and preclinical stages of research. To explore more about the same, we directed our search towards stem cell based, DNA based, or RNA based vaccines against COVID-19 under development by various universities, institutes or pharmaceutical companies. The current scientific literature and database search were performed by exploring various Trials registry (NIH: https://clinicaltrials.gov/ and https://www.coronavirus.gov) and Chinese clinical trial registry http://www.chictr.org.cn/) and for preclinical trials various University, Institutions, Pharmaceutical companies websites and news bulletins along with google search were checked routinely from 3rd March 2020 to 16 May 2020. The term "Stem Cell therapy and COVID-19", "Mesenchymal stem cell and corona 2019 virus", "DNA Vaccines and COVID-19, RNA Vaccines and COVID-19" and "Cell-based therapy with SARS-CoV-2, University/Institutions and COVID-19 research" were used. The vaccine trials (Stem Cells/DNA/RNA) which were cancelled were not included in this review. Similarly, few others like repurposing of drugs, Nano Vaccines, other miscellaneous trials of Herbs, Music therapy etc., were also excluded. In the present review, we have included the various novel therapies like stem cell therapy, DNA or RNA vaccines which are under development and if proven successful may have a lasting impact on the health industry.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32837030</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>28</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0970-1915</ISSN><JournalIssue CitedMedium="Print"><PubDate><Year>2020</Year><Month>Jul</Month><Day>10</Day></PubDate></JournalIssue><Title>Indian journal of clinical biochemistry : IJCB</Title><ISOAbbreviation>Indian J Clin Biochem</ISOAbbreviation></Journal><ArticleTitle>Novel Stem Cells and Nucleic Acid-Based Vaccine Trials Against Viral Outbreak: A Systematic Evaluation During COVID-2019 Pandemic.</ArticleTitle><Pagination><MedlinePgn>1-13</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s12291-020-00907-4</ELocationID><Abstract><AbstractText>The current Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) outbreak, the cause of coronavirus disease (COVID-19), has influenced health globally. So far, there are no established management options and prophylaxis for those who have been exposed to SARS-CoV-2, and those who develop COVID-19. Documented scientific evidences in similar viral outbreaks in past suggested few therapy regimens. These rather have not shown promising results in management of current pandemic. So, in the current review, we are exploring novel treatment strategies and therapies that are being explored and are in clinical and preclinical stages of research. To explore more about the same, we directed our search towards stem cell based, DNA based, or RNA based vaccines against COVID-19 under development by various universities, institutes or pharmaceutical companies. The current scientific literature and database search were performed by exploring various Trials registry (NIH: https://clinicaltrials.gov/ and https://www.coronavirus.gov) and Chinese clinical trial registry http://www.chictr.org.cn/) and for preclinical trials various University, Institutions, Pharmaceutical companies websites and news bulletins along with google search were checked routinely from 3rd March 2020 to 16 May 2020. The term "Stem Cell therapy and COVID-19", "Mesenchymal stem cell and corona 2019 virus", "DNA Vaccines and COVID-19, RNA Vaccines and COVID-19" and "Cell-based therapy with SARS-CoV-2, University/Institutions and COVID-19 research" were used. The vaccine trials (Stem Cells/DNA/RNA) which were cancelled were not included in this review. Similarly, few others like repurposing of drugs, Nano Vaccines, other miscellaneous trials of Herbs, Music therapy etc., were also excluded. In the present review, we have included the various novel therapies like stem cell therapy, DNA or RNA vaccines which are under development and if proven successful may have a lasting impact on the health industry.</AbstractText><CopyrightInformation>© Association of Clinical Biochemists of India 2020.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Maurya</LastName><ForeName>Chandan Kumar</ForeName><Initials>CK</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, 273008 India.</Affiliation><Identifier Source="GRID">grid.413618.9</Identifier><Identifier Source="ISNI">0000 0004 1767 6103</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Misra</LastName><ForeName>Radhieka</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Era's Lucknow Medical College, and Hospital, Lucknow, 226003 India.</Affiliation><Identifier Source="GRID">grid.414540.0</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sharma</LastName><ForeName>Praveen</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, 342005 India.</Affiliation><Identifier Source="GRID">grid.413618.9</Identifier><Identifier Source="ISNI">0000 0004 1767 6103</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Singh</LastName><ForeName>Neha</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Biotechnology, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, 211007 India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Awasthi</LastName><ForeName>Harshita</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, Lucknow University Lucknow, Lucknow, 226007 India.</Affiliation><Identifier Source="GRID">grid.411488.0</Identifier><Identifier Source="ISNI">0000 0001 2302 6594</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Agrawal</LastName><ForeName>Ruchika</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Ear Nose and Throat, All India Institute of Medical Sciences, Gorakhpur, 273008 India.</Affiliation><Identifier Source="GRID">grid.413618.9</Identifier><Identifier Source="ISNI">0000 0004 1767 6103</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Misra</LastName><ForeName>Sanjeev</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Surgical Oncology, All India Institute of Medical Sciences, Jodhpur, 342005 India.</Affiliation><Identifier Source="GRID">grid.413618.9</Identifier><Identifier Source="ISNI">0000 0004 1767 6103</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dwivedi</LastName><ForeName>Shailendra</ForeName><Initials>S</Initials><Identifier Source="ORCID">0000-0003-2781-1009</Identifier><AffiliationInfo><Affiliation>Department of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, 273008 India.</Affiliation><Identifier Source="GRID">grid.413618.9</Identifier><Identifier Source="ISNI">0000 0004 1767 6103</Identifier></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>India</Country><MedlineTA>Indian J Clin Biochem</MedlineTA><NlmUniqueID>8708303</NlmUniqueID><ISSNLinking>0970-1915</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">DNA vaccine</Keyword><Keyword MajorTopicYN="N">Nucleic acid based vaccines</Keyword><Keyword MajorTopicYN="N">RNA vaccine</Keyword><Keyword MajorTopicYN="N">Stem cell based vaccine</Keyword><Keyword MajorTopicYN="N">Viral disease</Keyword></KeywordList><CoiStatement>Conflict of interestThe authors declare that they have no conflict of interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>06</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32837030</ArticleId><ArticleId IdType="doi">10.1007/s12291-020-00907-4</ArticleId><ArticleId IdType="pii">907</ArticleId><ArticleId IdType="pmc">PMC7347658</ArticleId></ArticleIdList><pmc-dir>pmcsd</pmc-dir>
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sort="Awasthi, Harshita" uniqKey="Awasthi H" first="Harshita" last="Awasthi">Harshita Awasthi</name><name sortKey="Dwivedi, Shailendra" sort="Dwivedi, Shailendra" uniqKey="Dwivedi S" first="Shailendra" last="Dwivedi">Shailendra Dwivedi</name><name sortKey="Misra, Radhieka" sort="Misra, Radhieka" uniqKey="Misra R" first="Radhieka" last="Misra">Radhieka Misra</name><name sortKey="Misra, Sanjeev" sort="Misra, Sanjeev" uniqKey="Misra S" first="Sanjeev" last="Misra">Sanjeev Misra</name><name sortKey="Sharma, Praveen" sort="Sharma, Praveen" uniqKey="Sharma P" first="Praveen" last="Sharma">Praveen Sharma</name><name sortKey="Singh, Neha" sort="Singh, Neha" uniqKey="Singh N" first="Neha" last="Singh">Neha Singh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Novel Stem Cells and Nucleic Acid-Based Vaccine Trials Against Viral Outbreak: A Systematic Evaluation During COVID-2019 Pandemic.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32837030" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidPublicV1
| This area was generated with Dilib version V0.6.38. |  |